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Baclosign (Baclofen) 10 mg - 10 tablets

Baclosign (Baclofen) 10 mg – 10 tablets

6,80 $

Baclosign 10 mg. is an oral skeletal muscle relaxant whose active ingredient baclofen is used to reduce muscle spasticity.

SKU: BACL10 Category:

Description

Baclosign (Baclofen) 10 mg

Baclosign 10 mg contains baclofen, an oral prescription medicine used as an antispastic skeletal muscle relaxant. Verified prescribing information for baclofen tablets identifies it as a medicine for spasticity related mainly to multiple sclerosis and, in some cases, spinal cord disease or injury. It is not established as treatment for skeletal muscle spasm from rheumatic disorders, and its use in stroke, cerebral palsy, and Parkinson’s disease is not recommended in the official labeling.

Active Ingredient and Medicine Class

The active ingredient is baclofen. It belongs to the class of centrally acting muscle relaxants and antispastic agents. Baclofen is also described in official labeling as a GABAergic agonist, with activity at the spinal level.

Established Medical Uses

Official prescribing information supports baclofen tablets for the relief of signs and symptoms of spasticity associated with multiple sclerosis, especially flexor spasms, pain linked to spasms, clonus, and muscular rigidity. It may also be of value in some patients with spinal cord injuries and other spinal cord diseases when spasticity is considered reversible and treatment may help restore residual function.

How It Works

Baclofen acts mainly within the central nervous system. It inhibits monosynaptic and polysynaptic reflex activity at the spinal level, which helps reduce excessive muscle tone and involuntary spasms. The drug is structurally related to gamma-aminobutyric acid, and its clinical effects are thought to involve stimulation of GABA-B receptors and decreased release of excitatory neurotransmitters from nerve terminals.

Important Safety Information

Baclofen is contraindicated in patients with hypersensitivity to baclofen. Important cautions in official labeling include renal impairment, because the drug is primarily excreted unchanged by the kidneys, and epilepsy, where seizure control may occasionally worsen. Baclofen can cause sedation, and its central nervous system effects may be additive with alcohol and other CNS depressants. Abrupt discontinuation has been associated with serious withdrawal reactions, including hallucinations and seizures. Official labeling also warns about neonatal withdrawal symptoms when baclofen is used during pregnancy. Baclofen should be used cautiously when spasticity contributes to posture or balance, because reducing tone may sometimes affect function.

Possible Side Effects

The most commonly reported adverse effect is drowsiness. Other frequent effects include dizziness, weakness, fatigue, nausea, confusion, headache, insomnia, constipation, and urinary frequency. Less common but clinically important reactions reported in labeling include hallucinations, depression, hypotension, urinary retention, rash, and seizure. Overdose may cause profound drowsiness, respiratory depression, hypotonia, and loss of consciousness.

Scientific Evidence

Peer-reviewed reviews describe oral baclofen as a long-established option for spasticity, with evidence of benefit in many patients across different underlying conditions. However, the same literature notes that adverse effects can limit usefulness, and that oral therapy may be less tolerable than alternative approaches in some patients. Reviews also support the view that baclofen’s role is strongest in spasticity of spinal origin, while benefit in some other neurological conditions is less consistent.

Medical Information Notice

This page is an educational summary based on sources available at the time of review. It does not replace the official patient leaflet, product label, or assessment by a qualified healthcare professional.

Medical Sources

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