Description
Krrista Power
Krrista Power is identified as a combination product containing vardenafil 20 mg and dapoxetine 60 mg. Based on the verified ingredients, it combines a phosphodiesterase type 5 (PDE5) inhibitor used for erectile dysfunction with a short-acting selective serotonin reuptake inhibitor used for premature ejaculation. Regulatory sources confirm vardenafil as an ED medicine, and EMA documentation confirms dapoxetine as the active substance in Priligy for premature ejaculation.
Active Ingredient and Medicine Class
Vardenafil is a PDE5 inhibitor. Dapoxetine is a selective serotonin reuptake inhibitor (SSRI) with short-acting pharmacology. These medicines act on different pathways and are used for different sexual function disorders.
Established Medical Uses
Vardenafil is indicated for the treatment of erectile dysfunction. Dapoxetine has been used for the on-demand treatment of premature ejaculation in adult men. Clinical studies have evaluated dapoxetine in men with premature ejaculation and concomitant erectile dysfunction who were already using a PDE5 inhibitor, showing improvement in ejaculation-related outcomes compared with placebo.
How It Works
Vardenafil works by enhancing the nitric oxide–cGMP pathway in penile tissue, which helps improve blood flow during sexual stimulation. Dapoxetine increases serotonin signaling by blocking serotonin reuptake, which can help delay ejaculation. The combination is intended to address both erection difficulty and premature ejaculation, although clinical benefit can vary between individuals.
Important Safety Information
Vardenafil should not be used with nitrates because of the risk of marked hypotension. Official prescribing information also warns about clinically important interactions with alpha-blockers and other blood-pressure-lowering medicines. Dapoxetine is a serotonergic medicine and should not be combined with MAO inhibitors; caution is also warranted with other serotonergic drugs because of the risk of serotonin syndrome. Dapoxetine can also cause fainting or dizziness in some patients.
Possible Side Effects
Commonly reported adverse effects of vardenafil include headache, flushing, nasal congestion, and dyspepsia. Dapoxetine is commonly associated with nausea, dizziness, headache, and diarrhea. More serious reactions can include symptomatic low blood pressure, syncope, visual changes, priapism with PDE5 inhibitors, and serotonin syndrome with serotonergic combinations.
Scientific Evidence
Randomized clinical evidence shows that dapoxetine improves intravaginal ejaculatory latency time and patient-reported outcomes in premature ejaculation, including in men with concomitant erectile dysfunction already receiving a PDE5 inhibitor. A phase III study in such men found greater improvement with dapoxetine than placebo, with adverse events mainly reflecting known dapoxetine effects.
Medical Information Notice
This summary is for educational use only and is based on sources available at the time of review. It does not replace the official patient leaflet, product labeling, or assessment by a qualified healthcare professional.
Medical Sources
- U.S. Food and Drug Administration / DailyMed: Vardenafil tablets, prescribing information. View source
- European Medicines Agency: Priligy (dapoxetine) summary of product characteristics. View source
- McMahon CG et al. “Efficacy and safety of dapoxetine in men with premature ejaculation and concomitant erectile dysfunction treated with a phosphodiesterase type 5 inhibitor: randomized, placebo-controlled, phase III study.” Journal of Sexual Medicine (2013). PubMed
