Description
Sildalist (Sildenafil + Tadalafil) 120 mg
Sildalist 120 mg is a combination product identified as containing sildenafil and tadalafil, two phosphodiesterase type 5 (PDE5) inhibitors used in the treatment of erectile dysfunction. Official prescribing information is available for sildenafil and tadalafil as separate medicines, but this fixed-dose combination itself is not established in the regulatory sources reviewed here.
Active Ingredient and Medicine Class
The verified active ingredients are sildenafil and tadalafil. Both belong to the PDE5 inhibitor class, which increases blood flow in the penis by enhancing the effects of nitric oxide and cyclic guanosine monophosphate (cGMP).
Established Medical Uses
Sildenafil and tadalafil are established treatments for erectile dysfunction in adult men. Tadalafil is also approved in some products for benign prostatic hyperplasia or pulmonary arterial hypertension, depending on formulation, while sildenafil is also approved in some formulations for pulmonary arterial hypertension. The combination of sildenafil with tadalafil is not a standard approved indication in the sources reviewed.
How It Works
PDE5 inhibitors help preserve cGMP in penile tissue, which supports relaxation of smooth muscle and increased blood flow during sexual stimulation. Sildenafil and tadalafil act through the same pathway; tadalafil generally has a longer duration of action than sildenafil.
Important Safety Information
Both ingredients are contraindicated with any form of organic nitrate because of the risk of marked blood-pressure lowering. Caution is also required with alpha-blockers, antihypertensives, riociguat, and substantial alcohol intake, as these may further increase hypotension risk. The class should also be used carefully in people with cardiovascular disease for whom sexual activity is inadvisable. Labeling also warns about hypersensitivity, priapism risk, and rare sudden vision or hearing problems. Combination use of one PDE5 inhibitor with another erectile dysfunction therapy has not been adequately studied.
Possible Side Effects
Common adverse effects reported with sildenafil and tadalafil include headache, flushing, dyspepsia, nasal congestion, back pain, and muscle pain. More serious reactions can include prolonged erection, low blood pressure, chest symptoms, sudden loss of vision, and sudden hearing changes.
Scientific Evidence
Peer-reviewed studies show that sildenafil and tadalafil are both effective for erectile dysfunction, with broadly similar overall efficacy and safety in comparative analyses. Some evidence suggests tadalafil may be preferred by many patients because of its longer window of effect, while adverse-effect patterns differ somewhat between the two medicines. However, the reviewed literature compares the individual drugs, not this fixed-dose combination as a standard regulated product.
Medical Information Notice
This summary is for educational purposes only and is based on sources available at the time of review. It does not replace the official patient leaflet, prescribing information, or assessment by a qualified health professional.
Medical Sources
- DailyMed / FDA: Tadalafil tablet, film coated — Full prescribing information
- DailyMed / FDA: Viagra (sildenafil citrate) tablets — Prescribing information
- Simon Blais et al.: “Direct comparison of tadalafil with sildenafil for the treatment of erectile dysfunction: a systematic review and meta-analysis.” International Urology and Nephrology, 2017. PubMed
