Description
Sildigra (Sildenafil) 100 mg
Sildigra 100 mg is identified here as a sildenafil product. Sildenafil is a prescription phosphodiesterase-5 (PDE5) inhibitor used for erectile dysfunction in adults. Because trade names can vary by market, the verified active ingredient is the key basis for this summary.
Active Ingredient and Medicine Class
Active ingredient: sildenafil citrate.
Medicine class: phosphodiesterase-5 (PDE5) inhibitor. This class increases blood flow in erectile tissue by enhancing the normal nitric oxide–cGMP signaling pathway.
Established Medical Uses
Sildenafil is established for the treatment of erectile dysfunction in adult men. Regulatory prescribing information also includes other approved uses for some sildenafil formulations in different strengths and products, but the verified use for this product description is erectile dysfunction.
How It Works
During sexual stimulation, nitric oxide helps produce cyclic guanosine monophosphate (cGMP), which relaxes smooth muscle in the penis and supports increased blood flow. Sildenafil blocks PDE5, the enzyme that breaks down cGMP, so the natural erectile response can be strengthened. It does not directly cause an erection without sexual stimulation.
Important Safety Information
Sildenafil must not be used with nitrates or nitric oxide donors because of the risk of a marked drop in blood pressure. It is also contraindicated in people with known hypersensitivity to sildenafil or any tablet component. Prescribing information warns about clinically important interactions with alpha-blockers and other medicines that can lower blood pressure, as well as with strong CYP3A4 inhibitors that can raise sildenafil exposure. It should not be combined with other PDE5 inhibitors or other erectile dysfunction therapies.
Prescribers also consider cardiovascular status, because sexual activity itself may pose risk in some patients with heart disease. Rare but serious eye and hearing events have been reported with PDE5 inhibitors, and sudden vision or hearing loss requires urgent medical attention.
Possible Side Effects
Common adverse effects include headache, flushing, indigestion or dyspepsia, nasal congestion, dizziness, and abnormal or blurred vision. Less common but serious reactions can include severe hypotension, priapism, sudden vision loss, and sudden hearing loss.
Scientific Evidence
Clinical trials and systematic reviews show that sildenafil improves erectile function in many adult men with erectile dysfunction, with the best evidence for symptomatic benefit and generally acceptable tolerability. Review articles also describe a well-characterized PDE5 mechanism and a safety profile that is strongly influenced by nitrate co-use and cardiovascular risk factors.
Medical Information Notice
This summary is based on sources available at the time of review and is provided for educational purposes only. It does not replace the official patient leaflet, prescribing information, or assessment by a qualified healthcare professional.
Medical Sources
- DailyMed / FDA: Sildenafil Tablets, prescribing information
- Francis SH, et al.: Sildenafil: efficacy, safety, tolerability and mechanism of action in treating erectile dysfunction (Expert Opin Drug Metab Toxicol, 2005)
