Description
Sildigra (Sildenafil) 120 mg
Sildigra is presented here as a sildenafil product. Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor used for erectile dysfunction in adult men. Regulatory sources describe sildenafil as a medicine for achieving or maintaining an erection sufficient for satisfactory sexual performance, and note that sexual stimulation is required for it to work.
Active Ingredient and Medicine Class
The verified active ingredient is sildenafil, commonly supplied as sildenafil citrate. It belongs to the PDE5 inhibitor class and is also grouped pharmacologically among medicines used in erectile dysfunction.
Established Medical Uses
Sildenafil is established for the treatment of erectile dysfunction in adult men. Official product information from the FDA and EMA describes this indication consistently.
How It Works
Sildenafil helps by inhibiting PDE5, an enzyme that breaks down cyclic GMP in penile tissue. This supports the nitric oxide–cGMP pathway involved in smooth muscle relaxation and increased blood flow during sexual stimulation.
Important Safety Information
Sildenafil must not be used with nitrates or nitric oxide donors, because the combination can cause a marked drop in blood pressure. It is also contraindicated with guanylate cyclase stimulators such as riociguat and in people with known hypersensitivity to sildenafil.
Caution is advised in people for whom sexual activity is inadvisable because of cardiovascular status, and in patients taking alpha-blockers or antihypertensive medicines due to additive blood-pressure-lowering effects. Exposure may also be increased with strong CYP3A4 inhibitors such as ritonavir, ketoconazole, itraconazole, saquinavir and erythromycin.
Important warnings include priapism, sudden visual loss that may signal NAION, and sudden hearing loss.
Possible Side Effects
Common adverse effects include headache, flushing, dyspepsia, nasal congestion, back pain, muscle pain, nausea, dizziness, rash and abnormal vision. Less common but serious reactions can include prolonged erection, significant hypotension, visual or hearing disturbance, and cardiovascular events reported after use.
Scientific Evidence
Clinical reviews and meta-analyses indexed in PubMed show that sildenafil is effective for erectile dysfunction and is generally well tolerated in studied adult populations. Review data also support its mechanism through PDE5 inhibition and its established safety profile, while noting class-related adverse effects and interaction risks.
Medical Information Notice
This page is an educational summary based on sources available at the time of review and does not replace the official patient leaflet or individual assessment by a qualified healthcare professional.
Medical Sources
- U.S. Food and Drug Administration (FDA), Label: sildenafil tablets
- European Medicines Agency (EMA), Viagra: EPAR – Product information
- Francis SH et al., “Sildenafil: efficacy, safety, tolerability and mechanism of action in treating erectile dysfunction,” Expert Opinion on Drug Metabolism & Toxicology, 2005. PubMed
