Description
Tadalista (Tadalafil) 20 mg
Tadalista 20 mg is a brand-name product identified here as containing tadalafil, a prescription phosphodiesterase type 5 (PDE5) inhibitor used for erectile dysfunction. Official prescribing information for tadalafil tablets supports erectile dysfunction as an established use and describes a longer duration of effect compared with some other PDE5 inhibitors.
Active Ingredient and Medicine Class
Active ingredient: tadalafil.
Medicine class: phosphodiesterase type 5 (PDE5) inhibitor. This class acts on the nitric oxide–cGMP pathway involved in smooth muscle relaxation and blood flow in erectile tissue.
Established Medical Uses
Tadalafil tablets are indicated for the treatment of erectile dysfunction in adult men. In some regulatory jurisdictions, tadalafil is also approved for benign prostatic hyperplasia and for erectile dysfunction with benign prostatic hyperplasia, but those uses are separate from the product description provided here.
How It Works
Tadalafil helps preserve cGMP activity by inhibiting PDE5. This supports relaxation of smooth muscle in the penis during sexual stimulation, which can improve blood flow and help produce an erection. Clinical reviews describe tadalafil as having a relatively long half-life and a prolonged window of effect.
Important Safety Information
Tadalafil must not be used with nitrates because the combination can cause a dangerous drop in blood pressure. Caution is also required with alpha-blockers, antihypertensive medicines, alcohol, and strong CYP3A4 inhibitors such as ketoconazole or ritonavir, because these can increase hypotension risk or tadalafil exposure. It is not recommended in severe hepatic impairment, and use is limited in significant renal impairment. Priapism, sudden loss of vision, and sudden loss of hearing are important rare safety concerns.
Possible Side Effects
Common adverse effects include headache, dyspepsia, back pain, myalgia, nasal congestion, flushing, and pain in a limb. Less common but serious reactions can include prolonged erection, marked blood pressure lowering, visual changes, hearing loss, and hypersensitivity-type reactions.
Scientific Evidence
PubMed-indexed reviews and clinical studies report that tadalafil improves erectile function across a range of erectile dysfunction causes and severities. Evidence also supports its longer therapeutic window, with clinical benefit lasting up to about 36 hours after dosing in use-as-needed studies, and systematic reviews have examined daily versus on-demand regimens.
Medical Information Notice
This summary is for educational purposes only, based on sources available at the time of review. It does not replace the official patient leaflet, full prescribing information, or assessment by a qualified healthcare professional.
Medical Sources
- DailyMed (U.S. National Library of Medicine): Tadalafil tablets, full prescribing information
- Eric J H Meuleman: Review of tadalafil in the treatment of erectile dysfunction. Expert Opin Pharmacother. 2003.
