Description
Vega-extra cobra (Sildenafil) 200 mg
Vega-extra cobra 200 mg is identified as a sildenafil product. Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor used for erectile dysfunction in men. Because the brand name is not widely verifiable from official regulatory sources, the description below is based on the verified active ingredient, sildenafil.
Active Ingredient and Medicine Class
Active ingredient: sildenafil.
Medicine class: phosphodiesterase type 5 (PDE5) inhibitor. Sildenafil is a vasodilatory agent that acts through the nitric oxide/cyclic GMP pathway.
Established Medical Uses
Sildenafil is established for the treatment of erectile dysfunction. Official prescribing information describes it as indicated to improve erectile function in men with ED. Clinical reviews and systematic reviews support its effectiveness compared with placebo in improving erections and successful intercourse.
How It Works
Sildenafil inhibits PDE5, the enzyme that breaks down cyclic guanosine monophosphate (cGMP) in penile tissue. By preserving cGMP, it supports smooth-muscle relaxation and increased blood flow during sexual stimulation, which can help produce and maintain an erection. It does not cause an erection by itself without sexual stimulation.
Important Safety Information
Sildenafil must not be used with nitrates or nitric oxide donors because of the risk of marked blood pressure lowering. It is also contraindicated with riociguat. Official product information also lists caution or contraindication in men for whom sexual activity is inadvisable, and in patients with severe cardiovascular disease, severe hepatic impairment, hypotension, recent stroke or myocardial infarction, hereditary retinal disorders such as retinitis pigmentosa, and prior non-arteritic anterior ischaemic optic neuropathy with vision loss in one eye. Strong CYP3A4 inhibitors such as ritonavir can increase exposure.
Possible Side Effects
Common adverse effects include headache, flushing, dyspepsia, nasal congestion, dizziness, rash, and visual disturbance such as abnormal vision or colour change. Less common but serious reactions can include severe hypotension, priapism, sudden loss of vision, and sudden hearing changes. Hypersensitivity reactions have also been reported.
Scientific Evidence
Peer-reviewed reviews and meta-analyses show that sildenafil is more effective than placebo for erectile dysfunction and is generally well tolerated in clinical trials. Reported harms are usually transient and mild to moderate, with headache, flushing, and dyspepsia among the most frequent.
Medical Information Notice
This summary is an educational overview based on sources available at the time of review. It does not replace the official patient leaflet, prescribing information, or individual assessment by a qualified healthcare professional.
Medical Sources
- DailyMed — Sildenafil tablets, full prescribing information
- Medicines.org.uk (emc) — Sildenafil 100 mg film-coated tablets, Summary of Product Characteristics
- Tsertsvadze A, et al. — Oral sildenafil citrate (Viagra) for erectile dysfunction: a systematic review and meta-analysis of harms — Urology, 2009
