Description
Charam spray (Sildenafil)
Charam spray is identified by the supplied product name as a sildenafil-containing medicine. Sildenafil is a well-established prescription medicine used for erectile dysfunction in adult men. The exact branded spray formulation could not be verified from official regulatory sources, so this overview is based on sildenafil as the verified active ingredient.
Active Ingredient and Medicine Class
The verified active ingredient is sildenafil, a phosphodiesterase type 5 (PDE5) inhibitor. It is a vasodilating medicine that acts through the nitric oxide–cGMP pathway. Sildenafil is also marketed in other approved formulations, including tablets and oral suspension, for specific indications depending on the product label.
Established Medical Uses
Sildenafil is established for the treatment of erectile dysfunction in adult men. Official labels also describe other approved uses for sildenafil in different formulations, such as pulmonary arterial hypertension, but those uses are product-specific and are not assumed for this spray product.
How It Works
Sildenafil inhibits PDE5, the enzyme that breaks down cyclic guanosine monophosphate (cGMP). By preserving cGMP in smooth muscle, it supports relaxation of blood vessels in erectile tissue and helps improve blood flow during sexual stimulation. This mechanism is the basis for its clinical effect in erectile dysfunction.
Important Safety Information
Sildenafil must not be used with nitrates or other nitric oxide donors because of the risk of marked blood pressure lowering. Caution is also required with alpha-blockers, other blood-pressure-lowering medicines, and strong CYP3A4 inhibitors such as ritonavir, ketoconazole, itraconazole, saquinavir, or erythromycin, which can increase sildenafil exposure. Official labels also warn about use in people for whom sexual activity is inadvisable because of cardiovascular status. Hypersensitivity to sildenafil is a contraindication.
Possible Side Effects
Common adverse effects reported with sildenafil include headache, flushing, dyspepsia, nasal congestion, and visual disturbances. Less common but important serious reactions include symptomatic hypotension, priapism, hypersensitivity reactions, and rare serious eye events such as sudden vision loss.
Scientific Evidence
Peer-reviewed reviews and meta-analyses show that sildenafil improves erectile function compared with placebo and is generally well tolerated in clinical trials. Harm analyses found higher rates of several non-serious adverse effects, while serious adverse events were uncommon and not clearly increased versus placebo in the studied populations.
Medical Information Notice
This summary is an educational overview based on sources available at the time of review. It does not replace the official patient leaflet, prescribing information, or assessment by a qualified healthcare professional.
Medical Sources
- DailyMed / FDA: VIAGRA (sildenafil citrate) tablets, for oral use — Prescribing information
- Sharron H. Francis et al.: “Sildenafil: efficacy, safety, tolerability and mechanism of action in treating erectile dysfunction.” Expert Opinion on Drug Metabolism & Toxicology (2005). PubMed article
