Description
Vega (Sildenafil) 100 mg
Vega 100 mg is a sildenafil-containing medicine presented as oral tablets. Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor used for erectile dysfunction in adult men. It is a prescription medicine in many markets and should be used only according to the official product information.
Active Ingredient and Medicine Class
The verified active ingredient is sildenafil. It belongs to the PDE5 inhibitor class. Medicines in this class increase blood flow in the penis by enhancing the normal nitric oxide–cGMP pathway involved in erection.
Established Medical Uses
Sildenafil is established for the treatment of erectile dysfunction. Regulatory labelling also notes that sexual activity itself may be inadvisable for some patients with certain heart or vascular conditions, so suitability is assessed individually in official prescribing information.
How It Works
Sildenafil inhibits PDE5, the enzyme that breaks down cyclic guanosine monophosphate (cGMP). By slowing cGMP breakdown, it helps preserve smooth-muscle relaxation and blood flow in the corpus cavernosum during sexual stimulation. It does not directly cause an erection without sexual stimulation.
Important Safety Information
Important contraindications include concurrent nitrate use, because sildenafil can markedly enhance the blood-pressure-lowering effects of nitrates. It is also contraindicated in people with known hypersensitivity to sildenafil or any tablet component. Official prescribing information warns against combining sildenafil with other PDE5 inhibitors or sildenafil-containing medicines used for other indications.
Major precautions include cardiovascular disease, low blood pressure, recent stroke or heart attack, significant liver or kidney impairment, and certain eye conditions such as non-arteritic anterior ischaemic optic neuropathy. Alpha-blockers and strong CYP3A4 inhibitors can increase the risk of hypotension or raise sildenafil exposure, so clinically important interactions must be reviewed in the official label.
Possible Side Effects
Common adverse effects include headache, flushing, nasal congestion, dyspepsia, dizziness and visual disturbance such as changes in colour perception or blurred vision. Less common but serious reactions can include severe low blood pressure, prolonged erection, sudden hearing loss, and rare serious eye events including vision loss.
Scientific Evidence
Clinical reviews and meta-analyses indexed in PubMed show that sildenafil improves erectile function compared with placebo in men with erectile dysfunction, with a generally well-characterised safety profile. Human studies and post-marketing reviews also support the main interaction risks, especially with nitrates and other vasodilators.
Medical Information Notice
This summary is an educational overview based on sources available at the time of review. It does not replace the official patient leaflet, full prescribing information, or assessment by a qualified healthcare professional.
Medical Sources
- DailyMed / FDA: Sildenafil Tablets, Full Prescribing Information
- Francis SH, et al. “Sildenafil: efficacy, safety, tolerability and mechanism of action in treating erectile dysfunction.” Expert Opinion on Drug Metabolism & Toxicology (2005). PubMed
