Description
Dapoforce (Dapoxetine) 60 mg
Dapoforce 60 mg is a branded tablet containing dapoxetine, a selective serotonin reuptake inhibitor (SSRI). It is used for the management of premature ejaculation in adult men, and the 60 mg strength identifies the medicine rather than a recommended dose for any individual.
Active Ingredient and Medicine Class
The verified active ingredient is dapoxetine. It belongs to the SSRI class, which alters serotonin signalling in the nervous system. Dapoxetine has been developed specifically for use in premature ejaculation rather than for long-term treatment of depression.
Established Medical Uses
Authoritative product information identifies dapoxetine as a medicine for premature ejaculation in adult men. This indication is restricted in official European product information to men aged 18 to 64 years. It is intended to help increase ejaculatory control and reduce distress associated with rapid ejaculation.
How It Works
Dapoxetine inhibits serotonin reuptake, which increases serotonin activity between nerve cells. In the context of premature ejaculation, this change is associated with delayed ejaculation and improved perceived control. The mechanism is consistent with the SSRI class, although dapoxetine is used in a distinct, on-demand way from many antidepressants.
Important Safety Information
Official product information lists several important situations in which dapoxetine should not be used, including hypersensitivity to dapoxetine, significant heart rhythm problems, heart failure, a history of fainting, certain psychiatric histories such as mania or severe depression, and moderate or severe liver impairment. It should also not be combined with monoamine oxidase inhibitors or thioridazine, and caution is needed with other serotonergic medicines because of the risk of serotonin syndrome. Product information also highlights clinically important interactions with potent CYP3A4 inhibitors, including some antifungals, antivirals and other medicines, and advises avoiding grapefruit juice because it can increase exposure. Alcohol can increase dizziness and fainting risk.
Possible Side Effects
The most commonly reported adverse effects in clinical studies include nausea, dizziness, headache and diarrhoea. Fainting or near-fainting, blood pressure changes, sleepiness, palpitations and mood-related effects have also been reported. Rare but serious reactions may include serotonin syndrome, severe syncope, allergic reactions and clinically significant psychiatric symptoms. Side effects may be more likely when dapoxetine is combined with interacting medicines or alcohol.
Scientific Evidence
Randomized controlled trials and review evidence show that dapoxetine can improve intravaginal ejaculatory latency time and patient-reported control over ejaculation compared with placebo. In a large phase III trial, dapoxetine 30 mg and 60 mg improved multiple patient-reported outcomes, with the 60 mg arm showing greater efficacy but also more adverse events than placebo. A later review of randomized studies concluded that dapoxetine was effective for men with premature ejaculation, but tolerability remained an important limitation, particularly at the higher strength.
Medical Information Notice
This page is an educational summary based on sources available at the time of review. It does not replace the official patient leaflet, local prescribing information, or individual assessment by a qualified healthcare professional.
Medical Sources
- European Medicines Agency (EMA) Priligy referral page and product information for dapoxetine. View official medicine information
- electronic Medicines Compendium (emc) Priligy 30 mg and 60 mg film-coated tablets: Package Leaflet. View official patient leaflet
- Jacques Buvat et al. Dapoxetine for the treatment of premature ejaculation: results from a randomized, double-blind, placebo-controlled phase 3 trial in 22 countries. European Urology, 2009. View scientific article
- Sheridan M Hoy et al. Dapoxetine: in premature ejaculation. Drugs, 2010. View scientific article
