Description
Melegra (Sildenafil) 100 mg
Melegra is identified here as a sildenafil 100 mg tablet. Sildenafil is a prescription phosphodiesterase type 5 (PDE5) inhibitor used for erectile dysfunction in men. It is a well-established medicine with known benefits, contraindications, interactions and side effects.
Active Ingredient and Medicine Class
The verified active ingredient is sildenafil. It belongs to the PDE5 inhibitor class. This group of medicines increases blood flow in the penis by enhancing the natural nitric oxide-cGMP pathway during sexual stimulation.
Established Medical Uses
Sildenafil tablets are indicated for the treatment of erectile dysfunction (ED). Clinical trials and reviews show improved erectile function and successful sexual intercourse compared with placebo in men with ED, including some patients with diabetes, cardiovascular disease, depression, neurological disorders and after prostate surgery.
How It Works
Sildenafil helps relax smooth muscle and widen blood vessels in the penis by inhibiting the PDE5 enzyme. This supports increased penile blood flow during sexual arousal. It does not cause an erection without sexual stimulation.
Important Safety Information
Sildenafil is contraindicated with organic nitrates and riociguat because of the risk of marked blood pressure lowering. It should also be used cautiously with alpha-blockers and other blood-pressure-lowering medicines because of additive hypotensive effects. Prescribing information warns that men for whom sexual activity is inadvisable because of cardiovascular status should not use sildenafil. Hypersensitivity to sildenafil or any tablet component is also a contraindication.
Possible Side Effects
Common adverse effects include headache, flushing, indigestion, nasal congestion, dizziness, back pain, myalgia, nausea and visual disturbance. Less common but serious reactions can include severe hypotension, chest pain, sudden vision loss, sudden hearing loss, prolonged erection and allergic reactions.
Scientific Evidence
Peer-reviewed reviews and meta-analyses show that sildenafil is more effective than placebo for improving erectile function and overall sexual performance in men with ED, while adverse effects are generally dose-related and usually mild to moderate. Safety concerns are greatest in patients taking nitrates or other medicines that substantially lower blood pressure.
Medical Information Notice
This page is an educational summary based on sources available at the time of review and does not replace the official patient leaflet or assessment by a qualified healthcare professional.
Medical Sources
- DailyMed / FDA label: SILDENAFIL tablet
- Andrea Salonia et al. “Sildenafil in erectile dysfunction: a critical review.” Current Medical Research and Opinion (2003). PubMed
