Description
P-force fort (Sildenafil) 150 mg
P-force fort is identified as a sildenafil-containing medicine. Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor used for erectile dysfunction in adult men. It is a prescription medicine in authorised products and is intended to support erectile response during sexual stimulation rather than act as an aphrodisiac.
Active Ingredient and Medicine Class
Active ingredient: sildenafil.
Medicine class: phosphodiesterase type 5 (PDE5) inhibitor. Sildenafil selectively inhibits PDE5, the enzyme that breaks down cyclic guanosine monophosphate (cGMP) in penile smooth muscle.
Established Medical Uses
Authorised sildenafil products are indicated for erectile dysfunction in adult men, meaning difficulty achieving or maintaining an erection sufficient for satisfactory sexual activity. Regulatory sources describe this as the established use for Viagra and related sildenafil products.
How It Works
During sexual stimulation, nitric oxide triggers formation of cGMP, which relaxes smooth muscle and increases blood flow into the penis. Sildenafil blocks PDE5, helping cGMP remain active for longer and thereby supporting erection in response to sexual stimulation.
Important Safety Information
Sildenafil must not be used with nitrates or nitric oxide donors because of the risk of marked blood pressure lowering. It is also contraindicated in people with known hypersensitivity to sildenafil or any tablet component. Authorised product information warns against use in patients where sexual activity is inadvisable and in certain cardiovascular or severe hepatic conditions.
Clinically significant interactions can occur with alpha-blockers and other medicines that lower blood pressure; product information advises caution because of additive hypotensive effects. Strong CYP3A4 inhibitors, including ritonavir, can increase sildenafil exposure and require special caution in authorised labeling.
Possible Side Effects
Common adverse effects reported with sildenafil include headache, flushing, indigestion or dyspepsia, nasal congestion, and visual disturbance. Important serious reactions can include hypotension, chest symptoms in susceptible patients, hypersensitivity reactions, and rare prolonged erection. Visual effects are biologically plausible because sildenafil has some activity against PDE6 at higher exposures.
Scientific Evidence
Peer-reviewed reviews consistently describe sildenafil as a selective PDE5 inhibitor that improves erectile function by enhancing the nitric oxide–cGMP pathway. Clinical literature also notes that its efficacy and overall safety established sildenafil as the prototype oral PDE5 inhibitor for erectile dysfunction, with adverse effects largely related to vasodilation and, less commonly, visual symptoms.
Medical Information Notice
This page is an educational summary based on sources available at the time of review and does not replace the official patient leaflet or individual assessment by a qualified healthcare professional.
Medical Sources
- European Medicines Agency (EMA): Viagra: EPAR
- FDA / DailyMed: VIAGRA (sildenafil citrate) tablet, film coated
- Hatzimouratidis K et al., Mechanisms of action of PDE5 inhibition in erectile dysfunction, International Journal of Impotence Research, 2004. PubMed
