Description
Tadapox (Tadalafil + Dapoxetine) 20 mg + 60 mg
Tadapox is a combination product name used for a tablet containing tadalafil and dapoxetine. The ingredients belong to different drug classes and are used to address two separate male sexual health conditions: erectile dysfunction and premature ejaculation. The fixed-dose combination itself is not identified in the cited official regulatory sources as an approved product, so the description below is based on the verified properties of the two active ingredients.
Active Ingredient and Medicine Class
Tadalafil is a phosphodiesterase type 5 (PDE5) inhibitor. Official prescribing information states that it is indicated for erectile dysfunction and, in some markets, for benign prostatic hyperplasia and the combination of both conditions.
Dapoxetine is a selective serotonin reuptake inhibitor used for premature ejaculation in men in jurisdictions where it is authorised. EMA product information identifies this use for men aged 18 to 64 years.
Established Medical Uses
Tadalafil is established for the treatment of erectile dysfunction. Dapoxetine is established for the treatment of premature ejaculation where approved. Clinical studies have evaluated the two medicines together in men who have both conditions, supporting the rationale for combination use, but that does not establish a universal regulatory approval for the fixed-dose product name Tadapox.
How It Works
Tadalafil helps relax smooth muscle and increase blood flow in the penis during sexual stimulation by inhibiting PDE5. Dapoxetine increases serotonin activity and can delay ejaculation by affecting ejaculatory control pathways. Together, they act on different parts of the sexual response cycle.
Important Safety Information
Tadalafil must not be used with nitrates, and it is also contraindicated with guanylate cyclase stimulators. It requires caution with alpha-blockers, antihypertensives, strong CYP3A4 inhibitors, cardiovascular disease, severe liver impairment, and significant kidney impairment. Tadalafil also carries warnings about prolonged erection, vision changes, sudden hearing loss, and bleeding-related interactions.
Dapoxetine has important interaction concerns with other serotonergic medicines, monoamine oxidase inhibitors, thioridazine, and potent CYP3A4 inhibitors, and it may be unsuitable in patients with certain cardiac, psychiatric, liver, or fainting-related risks.
Possible Side Effects
Commonly reported adverse effects with tadalafil include headache, dyspepsia, back pain, myalgia, nasal congestion, flushing, and dizziness. Dapoxetine commonly causes nausea, headache, diarrhea, dizziness, and orthostatic dizziness. Serious reactions are uncommon but can include syncope, significant blood pressure effects, priapism, severe hypersensitivity, and rare vision or hearing problems.
Scientific Evidence
Peer-reviewed studies have examined dapoxetine with PDE5 inhibitors and tadalafil with dapoxetine in men who have premature ejaculation, including those with concomitant erectile dysfunction. These studies generally found improved ejaculatory outcomes versus placebo or single-agent comparators, with adverse effects consistent with the known profiles of the individual medicines.
Medical Information Notice
This page is an educational summary based on sources available at the time of review and does not replace the official patient leaflet, product label, or an individual assessment by a qualified healthcare professional.
Medical Sources
- U.S. Food and Drug Administration (DailyMed): Tadalafil Tablets, Full Prescribing Information. View source
- European Medicines Agency: Priligy (dapoxetine), Article 29 referral product information. View source
- Dresser MJ et al. “Dapoxetine, a novel treatment for premature ejaculation, does not have pharmacokinetic interactions with phosphodiesterase-5 inhibitors.” International Journal of Impotence Research (2006). PubMed
