Description
Super krrista (Tadalafil + Dapoxetine)
Super krrista is a combination product identified as containing tadalafil and dapoxetine. Based on regulatory and scientific sources, tadalafil is a phosphodiesterase type 5 (PDE5) inhibitor used for erectile dysfunction, and dapoxetine is a selective serotonin reuptake inhibitor (SSRI) used for premature ejaculation.
Active Ingredient and Medicine Class
Tadalafil belongs to the PDE5 inhibitor class. It relaxes smooth muscle and improves blood flow in the penis during sexual stimulation. Dapoxetine is an SSRI with a short half-life, developed for on-demand treatment of premature ejaculation.
Established Medical Uses
Tadalafil is established for erectile dysfunction and, in some regulatory settings, benign prostatic hyperplasia. Dapoxetine is established for premature ejaculation in adult men. Combination use has been studied in men with both erectile dysfunction and premature ejaculation, but the specific fixed-dose product name here could not be verified as a separately authorised medicine from the supplied details alone.
How It Works
Tadalafil inhibits PDE5, which helps preserve cyclic GMP and supports erection in response to sexual stimulation. Dapoxetine inhibits serotonin reuptake, which can delay ejaculation and improve control over ejaculation.
Important Safety Information
Tadalafil is contraindicated with any form of organic nitrate and with guanylate cyclase stimulators such as riociguat because of the risk of marked hypotension. It also requires caution with alpha-blockers, antihypertensives, alcohol, CYP3A4 inhibitors, and in patients with cardiovascular disease, severe liver disease, or severe renal impairment. Dapoxetine is associated with important risks including syncope, serotonin syndrome with other serotonergic medicines, and interactions with MAO inhibitors and certain antidepressants; alcohol may increase fainting risk.
Possible Side Effects
Reported adverse effects of tadalafil include headache, dyspepsia, back pain, myalgia, nasal congestion, flushing, and limb pain. Dapoxetine commonly causes nausea, dizziness, headache, diarrhoea, somnolence, and insomnia; fainting and other serious reactions are less common but clinically important.
Scientific Evidence
Clinical studies show that dapoxetine improves ejaculatory latency and patient-reported control versus placebo in premature ejaculation. A randomized phase III study in men with premature ejaculation and concomitant erectile dysfunction treated with a PDE5 inhibitor found that dapoxetine improved latency and related outcomes with acceptable tolerability. A separate crossover study found no meaningful pharmacokinetic interaction between dapoxetine and tadalafil.
Medical Information Notice
This summary is provided for educational purposes only and is based on sources available at the time of review. It does not replace the official patient leaflet, prescribing information, or individual assessment by a qualified healthcare professional.
Medical Sources
- European Medicines Agency (EMA) — Priligy referral page
- DailyMed / FDA label — Tadalafil tablet, film coated
- McMahon CG et al. — “Efficacy and safety of dapoxetine in men with premature ejaculation and concomitant erectile dysfunction treated with a phosphodiesterase type 5 inhibitor: randomized, placebo-controlled, phase III study.” Journal of Sexual Medicine (2013). PubMed
- Dresser MJ et al. — “Dapoxetine, a novel treatment for premature ejaculation, does not have pharmacokinetic interactions with phosphodiesterase-5 inhibitors.” International Journal of Impotence Research (2006). PubMed
