Description
Varditra (Vardenafil) 40 mg
Varditra is presented as a vardenafil tablet. Vardenafil is a phosphodiesterase type 5 (PDE5) inhibitor used for erectile dysfunction. The product name and strength should be treated as identification details; verified medical information is based on vardenafil itself.
Active Ingredient and Medicine Class
The verified active ingredient is vardenafil, a selective PDE5 inhibitor. This class also includes other medicines used for erectile dysfunction. Vardenafil is an oral prescription medicine.
Established Medical Uses
Vardenafil is established for the treatment of erectile dysfunction. Regulatory labeling identifies this as its approved use. Clinical studies and reviews have shown improved erectile function in men with mild to severe erectile dysfunction, including men with various underlying causes.
How It Works
Vardenafil works by inhibiting PDE5, an enzyme involved in regulating blood flow in penile tissue. By blocking PDE5, it helps increase the effect of nitric oxide–related signaling and supports relaxation of smooth muscle and blood flow during sexual stimulation. It does not itself cause an erection without sexual stimulation.
Important Safety Information
Vardenafil is contraindicated with nitrates and nitric oxide donors because the combination can cause a marked drop in blood pressure. It should not be used with other erectile dysfunction therapies. Important interactions also occur with strong CYP3A4 inhibitors and some other medicines that can raise vardenafil exposure. Labeling also warns against use in patients with severe hepatic impairment.
Prescribing information also highlights caution in patients with cardiovascular risk factors and in those taking medicines that may further lower blood pressure.
Possible Side Effects
Common adverse effects include headache, flushing, nasal congestion, dyspepsia, dizziness, and back pain. Serious but less common reactions can include priapism, significant blood pressure effects, sudden changes in vision or hearing, and hypersensitivity reactions.
Scientific Evidence
Randomized controlled trials and systematic reviews have found that vardenafil improves erectile function and sexual encounter outcomes compared with placebo in men with erectile dysfunction. Available evidence also supports generally similar tolerability patterns to other PDE5 inhibitors, with headache and flushing among the most frequent treatment-related adverse effects.
Medical Information Notice
This page is an educational summary based on sources available at the time of review. It does not replace the official patient leaflet, prescribing information, or individual assessment by a qualified healthcare professional.
Medical Sources
- DailyMed / U.S. National Library of Medicine: Vardenafil Tablets, Full Prescribing Information
- Keating GM et al.: Vardenafil: a review of its use in erectile dysfunction, Drugs, 2003
