Description
Super krrista
Super krrista is identified by its stated composition as a combination of tadalafil and dapoxetine. Tadalafil is a phosphodiesterase type 5 (PDE5) inhibitor used for erectile dysfunction, while dapoxetine is a selective serotonin reuptake inhibitor (SSRI) used for premature ejaculation in some jurisdictions. The combination has been studied for men with premature ejaculation and coexisting erectile dysfunction, but the trade name itself could not be verified as an authorised medicine in the sources reviewed.
Active Ingredient and Medicine Class
Tadalafil belongs to the PDE5 inhibitor class. It helps improve penile blood flow during sexual stimulation by enhancing nitric oxide-mediated smooth muscle relaxation. Dapoxetine is a short-acting SSRI developed for premature ejaculation; it increases serotonin signalling in the nervous system.
Established Medical Uses
Tadalafil is established for erectile dysfunction and, in some authorised products, benign prostatic hyperplasia. Dapoxetine is authorised in the European Union for premature ejaculation in men aged 18 to 64 years. Published clinical studies have evaluated the tadalafil-dapoxetine combination in men with premature ejaculation, including men with erectile dysfunction, but the combination itself is not widely established as a standard authorised product in the sources reviewed.
How It Works
Tadalafil increases the effect of nitric oxide in penile tissue, which relaxes smooth muscle and supports erection during sexual stimulation. Dapoxetine delays ejaculation by increasing serotonin activity, which can improve ejaculatory control. The two mechanisms address different aspects of male sexual function.
Important Safety Information
Tadalafil must not be used with nitrates because the combination can cause dangerous hypotension. Important precautions also apply with alpha-blockers, antihypertensive medicines, potent CYP3A4 inhibitors, and in men with cardiovascular disease for whom sexual activity may be inadvisable. Dapoxetine should not be used with monoamine oxidase inhibitors, certain antidepressants, thioridazine, or in people with a history of syncope, mania, or severe depression. It may also be unsuitable in significant heart rhythm disorders.
Possible Side Effects
Commonly reported adverse effects with tadalafil include headache, dyspepsia, back pain, flushing, nasal symptoms, and dizziness. Rare but important reactions include marked blood pressure lowering, visual disturbances including NAION, and sudden hearing changes. Dapoxetine is commonly associated with nausea, dizziness, headache, diarrhoea, insomnia, somnolence, and occasionally syncope.
Scientific Evidence
Clinical evidence shows that dapoxetine improves intravaginal ejaculatory latency time and patient-reported control over ejaculation compared with placebo. Studies of tadalafil plus dapoxetine suggest the combination may improve outcomes in selected men with premature ejaculation, including those with erectile dysfunction, but the evidence base is smaller than for each medicine individually. Safety findings in studies generally reflect the known adverse effects of each component.
Medical Information Notice
This page is an educational summary based on sources available at the time of review and does not replace the official patient leaflet or assessment by a qualified healthcare professional.
Medical Sources
- European Medicines Agency (EMA): Priligy – referral
- FDA / DailyMed: DailyMed: Tadalafil tablet, film coated
- PubMed: Salonia A, et al. Efficacy and safety of dapoxetine in treatment of premature ejaculation: an evidence-based review. International Journal of Clinical Practice. 2016.
