Description
Nookie (Sildenafil + Dapoxetine) 100 mg + 60 mg
Nookie 100 mg + 60 mg is a combination medicine containing sildenafil and dapoxetine. The product is identified as a fixed-dose oral combination used in men with erectile dysfunction and premature ejaculation, but the exact trade-name authorisation for this specific product was not verified from an official regulator source. The information below is based on the verified active ingredients.
Active Ingredient and Medicine Class
Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor used for erectile dysfunction. Dapoxetine is a short-acting selective serotonin reuptake inhibitor (SSRI) developed for premature ejaculation. Both ingredients are established medicines in their respective areas, although they are not universally approved as a fixed-dose combination product.
Established Medical Uses
Sildenafil is established for erectile dysfunction. Dapoxetine is established for premature ejaculation in adult men in jurisdictions where it is authorised. Clinical studies have also evaluated dapoxetine together with sildenafil in men who have premature ejaculation and concomitant erectile dysfunction.
How It Works
Sildenafil helps relax smooth muscle and improve blood flow in the penis during sexual stimulation by enhancing the nitric oxide-cGMP pathway. Dapoxetine increases serotonin signalling in the nervous system, which can delay ejaculation and improve ejaculatory control. The combination is intended to address both erectile dysfunction and premature ejaculation in the same treatment approach.
Important Safety Information
Sildenafil must not be used with nitrates or nitric oxide donors because of the risk of marked blood pressure lowering. It also requires caution with alpha-blockers and other medicines that lower blood pressure. It is contraindicated in people with known hypersensitivity to sildenafil. Dapoxetine is contraindicated with monoamine oxidase inhibitors, thioridazine, other serotonergic antidepressants, and in patients with certain heart rhythm problems, a history of fainting, or other specified serious psychiatric or cardiovascular conditions. Potent CYP3A4 inhibitors can increase dapoxetine exposure. Both ingredients may increase the risk of adverse effects when used with other medicines affecting blood pressure or serotonin pathways.
Possible Side Effects
Commonly reported adverse effects include headache, flushing, dizziness, nausea, diarrhoea, palpitations, and nasal congestion. Dapoxetine studies also report postural dizziness and fainting in some patients. Sildenafil can also be associated with visual disturbance, dyspepsia, and rarely priapism or significant blood pressure effects. Serious reactions are uncommon but require prompt medical attention.
Scientific Evidence
Clinical evidence supports dapoxetine for premature ejaculation and sildenafil for erectile dysfunction separately. Studies of the combination have shown improvements in ejaculatory latency, erectile function scores, and patient-reported outcomes in men with both conditions, with mainly mild to moderate adverse events. However, the evidence base for the fixed-dose combination is smaller than for the individual medicines.
Medical Information Notice
This page is an educational summary based on sources available at the time of review. It does not replace the official patient leaflet, prescribing information, or individual assessment by a qualified health professional.
Medical Sources
- European Medicines Agency (EMA) — Priligy referral page
- DailyMed — VIAGRA (sildenafil citrate) tablet, film coated
- McMahon CG et al. — “Efficacy and safety of dapoxetine in men with premature ejaculation and concomitant erectile dysfunction treated with a phosphodiesterase type 5 inhibitor: randomized, placebo-controlled, phase III study” — The Journal of Sexual Medicine (2013). PubMed
