Description
Stenagra force
Stenagra force is a combination product identified as containing sildenafil and dapoxetine. Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor used for erectile dysfunction, while dapoxetine is a short-acting selective serotonin reuptake inhibitor (SSRI) developed for premature ejaculation. This is an educational summary based on the available sources and not a substitute for the official product information.
Active Ingredient and Medicine Class
Sildenafil belongs to the PDE5 inhibitor class. It increases blood flow in penile tissue by enhancing the nitric oxide–cGMP pathway. Dapoxetine is an SSRI with a short duration of action and is used for premature ejaculation in men. The combination is intended to address both erectile dysfunction and premature ejaculation in men with both conditions, but the exact trade name and strength should always be verified against authorised product information.
Established Medical Uses
Sildenafil is established for erectile dysfunction. Dapoxetine is established for the treatment of premature ejaculation in adult men in jurisdictions where it is authorised. Clinical studies have evaluated the combination in men with premature ejaculation and concomitant erectile dysfunction, showing improvement in ejaculation-related outcomes and erectile function measures.
How It Works
Sildenafil helps relax blood vessels in the penis, supporting erectile response during sexual stimulation. Dapoxetine increases serotonin signalling in the nervous system, which can delay ejaculation. Together, these actions may address two different sexual function problems at the same time.
Important Safety Information
Safety concerns reflect the combined risks of a PDE5 inhibitor and an SSRI. Sildenafil is contraindicated with nitrates because of the risk of marked hypotension, and caution is required with alpha-blockers and other blood-pressure-lowering medicines. Sildenafil exposure can also rise with strong CYP3A4 inhibitors. Dapoxetine should not be used with monoamine oxidase inhibitors, other serotonergic medicines, or in patients with a history of serious serotonin-related reactions, because of the risk of serotonin syndrome and related adverse effects. Dapoxetine is also associated with syncope and should be used cautiously in people with cardiovascular disease. As with other medicines in this class, authorised product information typically lists hypersensitivity as a contraindication.
Possible Side Effects
Commonly reported effects include headache, flushing, dizziness, nausea, palpitations, and gastrointestinal upset. More serious reactions may include low blood pressure, fainting, prolonged erection, priapism, and serotonin syndrome. Not all patients will experience these effects, and severity can vary.
Scientific Evidence
Clinical evidence in PubMed-indexed studies suggests that dapoxetine plus sildenafil can improve intravaginal ejaculatory latency time, patient-reported satisfaction, and erectile function in men with premature ejaculation and erectile dysfunction. Published trials also report that the combination was generally tolerated, although adverse effects occurred and were usually mild to moderate. The evidence base is still limited compared with the separate, well-established use of each medicine.
Medical Information Notice
This page is an educational summary based on sources available at the time of review. It does not replace the official patient leaflet, prescribing information, or assessment by a qualified health professional.
Medical Sources
- European Medicines Agency (EMA), Priligy – referral
- DailyMed / FDA, VIAGRA (sildenafil citrate) tablets, prescribing information
- Tuken M, et al., “Efficacy and safety of dapoxetine/sildenafil combination tablets in the treatment of men with premature ejaculation and concomitant erectile dysfunction-DAP-SPEED Study,” International Journal of Impotence Research (2019), PubMed
